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Methylation been found on a range of lysine residues in various histones: K4 (utilizing the single-letter amino-acid code for lysine), K9, K27, K36 and K79 in histone H3, K20 in histone H4, K59 in the globular domain of histone H4 2 and K26 of histone H1B three A number of proteins accountable for the methylation of particular residues have been characterized, and all however considered one of these incorporates a SET domain