Ipamorelin and CJC-1295 are two peptides often paired together to enhance growth hormone release in clinical and research settings. Their combination can lead to increased muscle mass, improved recovery, and better overall metabolic health when used responsibly under professional guidance.

CJC 1295 / Ipamorelin: Proper Dosage

For most users, a typical regimen involves subcutaneous injections of CJC-1295 at a dose ranging from 2.5 to 5 micrograms per kilogram of body weight. Ipamorelin is usually administered at an equal or slightly lower dose, such as 2.5 to 3.5 micrograms per kilogram. A common protocol is to inject both peptides once daily, preferably in the morning before breakfast. Some protocols split the dose into two injections—one in the morning and one in the evening—to maintain a steadier release of growth hormone throughout the day. The total weekly dosage can therefore fall between 35 to 70 micrograms per kilogram, depending on individual response and goals.

It is important to start at the lower end of the dosing range to assess tolerance. If no adverse effects occur after several weeks, the dose may be increased incrementally by 0.5 to 1 microgram per kilogram every two to four weeks. A standard maintenance phase often lasts between six and twelve weeks before a break or a reassessment is considered. Users should also monitor blood sugar levels, as growth hormone can influence insulin sensitivity.

Understanding Ipamorelin CJC 1295

Ipamorelin is a pentapeptide that acts as a selective growth hormone secretagogue. It mimics the action of ghrelin by binding to the GHS-R1a receptor on pituitary cells, stimulating the release of growth hormone without significantly affecting cortisol or prolactin levels. CJC-1295, also known as PEG-GHRP-2, is a longer-acting analog that contains a polyethylene glycol (PEG) moiety, which extends its half-life and allows for less frequent dosing.

When combined, these peptides create a synergistic effect: Ipamorelin provides a potent but short burst of growth hormone secretion, while CJC-1295 sustains the overall elevation by reducing peptide clearance. The result is a more pronounced and prolonged increase in circulating growth hormone and downstream insulin-like growth factor 1 (IGF-1). This combination can be especially useful for athletes or bodybuilders seeking muscle hypertrophy, fat loss, or enhanced recovery.

Definition and Function

Growth hormone secretagogues are compounds that stimulate the pituitary gland to produce and release growth hormone. Ipamorelin is a selective agonist of the ghrelin receptor